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KMID : 0366919990110000383
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Sungkyun Pharmceutical Journal
1999 Volume.11 No. 0 p.383 ~ p.388
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Two New Lignans from Lindera obtusiloba Blume
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Kwon, Hak Cheol
Choi, Sang Un/Lee, Jung Ock/Bae, Ki Hwan/Zee, Ok Pyo/Lee, Kang Ro
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Abstract
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Two new furanolignans (3, 5), together with three known lignans (1, 2, 4), were isolated from the stem of Lindera obtusiloba (Lauraceae). The structures of the compounds were determined as actifolin (1), pluviatilol (2), 5,6-dihydroxymatairesinol (3), (+)-syringaresinol (4), and (+)-9´-O-trans-feruloyl-5, 5´-dimethoxylariciresinol (5) on the basis of physicochemical and spectroscopic evidences. Compounds 1, 2, 3, and 5 showed cytotoxicity against a small panel of human tumor cell lines with ED_50 values of 3.40∼19.27 ㎍/ml.
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